But researchers warn they haven’t been shown to work or proven safe. Possible benefits for people are just emerging, and at least a dozen clinical trials with senolytics are now testing things like whether they can help control Alzheimer’s progression and improve skeletal health.Īmid the buzz, some companies market dietary supplements as senolytics. In mice, they’ve been shown to be effective at delaying, preventing or easing several age-related disorders. A paper he authored with colleague Paul Moorhead was rejected by a prominent scientific journal, and Hayflick faced a decade of ridicule after it was published in Experimental Cell Research in 1961.Įxperimental drugs designed to selectively clear senescent cells have been dubbed “senolytics,” and Mayo holds patents on some. The finding, Hayflick says, challenged “60-year-old dogma” that normal human cells could replicate forever. The phenomenon was later called “the Hayflick limit.” What was surprising was that others stopped dividing at the same point. This wasn’t a big surprise cell cultures often failed because of things like contamination. He discovered cellular senescence by accident, cultivating human fetal cells for a project on cancer biology and noticing they stopped dividing after about 50 population doublings. His scientific renown didn’t come easily. He’s a professor of anatomy at the University of California, San Francisco, and continues to write, present and speak on the topic. Leonard Hayflick, the scientist who discovered cellular senescence in 1960, is himself vital at 94. “I’m looking for the fountain of not being sick when I’m older.” “I’m not looking for the fountain of youth,” Wiley says. They accumulate in older bodies, which mounting evidence links to age-related conditions such as dementia, cardiovascular disease and osteoporosis. But as the Mayo Clinic's Nathan LeBrasseur puts it, they can harm nearby cells like moldy fruit corrupting a fruit bowl. It’s built upon the idea that cells eventually stop dividing and enter a “senescent” state in response to various forms of damage. But scientists are trying to change that - and tackle one of humanity’s biggest challenges - through a little known but flourishing field of aging research called cellular senescence.
It’s a goal that eludes so many that growing old is often associated with getting frail and sick. Soller, who lives near Cincinnati, has achieved an enviable goal chased by humans since ancient times: Staying healthy and active in late life. He proudly proclaims he’s never used it he’s been too busy training for competitions such as the National Senior Games.
Steps away is an expensive leather recliner he bought when he retired from Procter & Gamble with visions of relaxing into old age. Without a hint of breathlessness, he says: “I can put in miles down here.”
#Zombie quest full
In an unfinished part of his basement, 95-year-old Richard Soller zips around a makeshift track encircling boxes full of medals he’s won for track and field and long-distance running.
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